Related Experiment Video

Updated: Dec 26, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Hippo Signaling: Autophagy Waits in the Wings

Thomas P Neufeld1

  • 1Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.

Developmental Cell
|March 11, 2020
PubMed

Insights

Cell growth factor YAP/Yorkie and autophagy kinase Ulk1/Atg1 signaling pathways are interconnected. This crosstalk coordinates diverse cellular functions, revealing novel regulatory mechanisms in cell biology.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cellular functions are coordinated by complex signaling networks.
  • Understanding crosstalk between these networks is crucial for deciphering cellular regulation.

Purpose of the Study:

  • To investigate the connection between the YAP/Yorkie pathway, which promotes cell growth, and the Ulk1/Atg1 pathway, which regulates autophagy.
  • To elucidate how these two key signaling pathways interact.

Main Methods:

  • The study likely involved molecular biology techniques to analyze protein interactions and signaling pathway activity.
  • Experimental approaches may include Western blotting, immunoprecipitation, and gene silencing/overexpression studies.

Main Results:

  • Tyra et al. identified a direct or indirect link between YAP/Yorkie and Ulk1/Atg1.
  • This connection suggests a mechanism by which cell growth signaling influences autophagy.

Conclusions:

  • The findings reveal a novel crosstalk between cell growth and autophagy pathways.
  • This interaction provides new insights into the coordination of cellular functions and metabolic regulation.

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