Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.4K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.4K
Overview of Myosin Structure and Function01:15

Overview of Myosin Structure and Function

6.1K
Myosins are a family of molecular motor proteins, first identified in the skeletal muscles, where they are responsible for muscle contraction. Along with their role in muscle contraction, these proteins also play a role in the intracellular transport of molecules and vesicles. There are twenty-four classes of myosins based on their domain sequence and organization. Of the twenty-four, six classes (Myosin I, Myosin II, Myosin V, Myosin VI, Myosin VII, and Myosin X)  have been well...
6.1K
Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

6.3K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
6.3K
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

9.8K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
9.8K
The Sarcomere01:08

The Sarcomere

14.5K
A sarcomere is a microscopic segment repeating in a myofibril. The sarcomere fundamentally consists of two main myofilaments: thick filaments called myosin and thin filaments called actin. These filaments interact by sliding past each other in response to stimulus. In addition to myosin and actin, several other proteins, such as tropomyosin, troponin, titin, nebulin, myomesin, α-actinin, and dystrophin, play crucial roles in regulating, structuring, and functioning of the sarcomere.
Each...
14.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations between prediabetes, type 2 diabetes, and incident arrhythmias: a population-based cohort study and Mendelian randomization analysis.

Diabetes research and clinical practice·2026
Same author

Structure-Activity Relationship of Cycling Molecular Assemblies for Golgi Targeting and Disruption.

Journal of medicinal chemistry·2026
Same author

A DFT study on the structures, properties, and interfacial interactions of cage-like HMX@cyclo[n]carbons energetic composites.

Journal of molecular modeling·2026
Same author

Comparative Evaluation of Prolonged Dual Antiplatelet Therapy versus Conventional Regimens on Prognosis in Patients with High Residual Inflammatory Risk: Results from a Prospective Observational Study.

Journal of inflammation research·2026
Same author

The Association Between Fibrosis-4 Index and All-Cause and Cardiac Mortality in Patients With Coronary Heart Disease Combined With Diabetes or Prediabetes: Findings From Two Large-Scale Prospective Cohort Studies.

MedComm·2026
Same author

Data from the Researcher Mental Health Observatory STAIRCASE Survey.

Journal of open psychology data·2026

Related Experiment Video

Updated: Dec 26, 2025

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila
07:13

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila

Published on: January 7, 2019

14.5K

Atypical Myosin Tunes Dendrite Arbor Subdivision.

Li-Foong Yoong1, Hui-Keem Lim2, Heidi Tran1

  • 1Laboratory for Neurodiversity, RIKEN Center for Brain Science, Wako-shi, Saitama 351-0198, Japan.

Neuron
|March 11, 2020
PubMed
Summary

The atypical actin motor Myo6 unexpectedly shapes neuron dendrite primary branches. It guides microtubule dynamics and actin filament extension, crucial for defining neuronal function and arbor diversity.

Keywords:
automated feature detectionautomated neurite tracingbranchingdendritefascinfilopodiagrowth conemicrotubule polaritymyosintranscription factor

More Related Videos

Immunohistological Labeling of Microtubules in Sensory Neuron Dendrites, Tracheae, and Muscles in the Drosophila Larva Body Wall
07:49

Immunohistological Labeling of Microtubules in Sensory Neuron Dendrites, Tracheae, and Muscles in the Drosophila Larva Body Wall

Published on: November 10, 2011

12.7K
Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes
08:25

Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes

Published on: January 12, 2020

6.6K

Related Experiment Videos

Last Updated: Dec 26, 2025

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila
07:13

Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila

Published on: January 7, 2019

14.5K
Immunohistological Labeling of Microtubules in Sensory Neuron Dendrites, Tracheae, and Muscles in the Drosophila Larva Body Wall
07:49

Immunohistological Labeling of Microtubules in Sensory Neuron Dendrites, Tracheae, and Muscles in the Drosophila Larva Body Wall

Published on: November 10, 2011

12.7K
Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes
08:25

Retrograde Tracing of Drosophila Embryonic Motor Neurons Using Lipophilic Fluorescent Dyes

Published on: January 12, 2020

6.6K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Dendrite arbor patterns dictate neuronal function.
  • Primary branch structure is established by intrinsic and transcription-factor mechanisms.
  • Developing dendrites exhibit dynamic acentrosomal microtubule behavior.

Purpose of the Study:

  • Investigate the role of the atypical actin motor Myo6 in primary dendrite branch formation.
  • Elucidate the molecular mechanisms underlying dendrite arbor patterning.
  • Understand how cytoskeletal dynamics contribute to neuronal structure and function.

Main Methods:

  • In vivo time-lapse imaging of Drosophila adult sensory neuron differentiation.
  • Machine-learning-based quantification of arbor patterning.
  • Molecular-level tracking of cytoskeletal remodeling.

Main Results:

  • Myo6 specifies the position, polarity, and targeting of microtubule polymerization events.
  • Myo6 and the transcription factor Knot regulate transient microtubule polymerization surges at dendrite tips.
  • An actin filament array driven by Myo6 guides microtubule polymerization and branch subdivision.

Conclusions:

  • Myo6 plays a critical, unexpected role in establishing primary dendrite branch structure.
  • This actin motor-mediated mechanism is key for defining and diversifying dendrite arbor compartmentalization.
  • The findings reveal a novel link between actin dynamics and neuronal branching patterns.