Infant cancers in France: Incidence and survival (2000-2014)
Emmanuel Desandes1, Laure Faure2, Sandra Guissou1
1Registre National des cancers de l'Enfant, Registre National des Tumeurs Solides de l'Enfant, CHRU Nancy, Vandoeuvre-lès-Nancy, F-54500, France; Centre de Recherche en Epidémiologie et en Statistique Sorbonne-Paris Cité (CRESS), UMR 1153, INSERM, Université Paris, 75014, Paris, France.
Insights
Infant cancers in France are diagnosed in 185 children annually, with survival rates varying by cancer type. This study quantifies the burden of these rare childhood cancers.
Area of Science:
- Pediatric Oncology
- Epidemiology
- Cancer Research
Background:
- Approximately 185 children are diagnosed with cancer annually in France during their first year of life.
- This represents 11% of all childhood cancers diagnosed in children under 15 years old.
Purpose of the Study:
- To analyze the incidence, types, and survival outcomes of cancers diagnosed in infants in France.
- To understand the epidemiological burden of infant cancers and identify specific high-risk diagnoses.
Main Methods:
- A retrospective, population-based observational study was conducted using the French National Registry of Childhood Cancers Database.
- Data from 2000 to 2014 were analyzed for all infants diagnosed with primary cancers.
Main Results:
- Out of 2760 infant cancer cases, neuroblastomas (30.1%), central nervous system (CNS) tumors (16.1%), and leukemias (15.3%) were most common.
- The overall 5-year survival rate was 81.0%, with significant variations: retinoblastomas and hepatoblastomas had >85% survival, while acute myeloid leukemias and CNS tumors had <65% survival.
- No substantial changes in survival rates were observed between 2000-2004 and 2010-2014.
Conclusions:
- This study quantifies the impact of infant cancers on the French population.
- It highlights the significant burden of certain devastating infant cancers and emphasizes the need for continued research and improved treatment strategies.
Background:
On average 185 children are diagnosed each year in France with a cancer in their first year of life, representing 11 % of cancers diagnosed in children less than 15 years.
Methods:
A retrospective population-based observational study was conducted between 2000 and 2014 of all infants with a diagnosis of cancer using the National Registry of Childhood Cancers Database.
Results:
Out of 2760 cases of primary cancers in infancy, there were mainly neuroblastomas 30.1 %), central nervous system (CNS) tumors (16.1 %), leukemias (15.3 %), retinoblastomas (11.6 %), and Wilms tumors (6.9 %). Embryonal malignancies accounted for 55.2 % of cases. Most diagnoses showed a male excess, particularly for malignant gonadal germ-cell tumors (GCT) with a 17.5 sex-ratio. The annual incidence rate, 242.9 per million infants overall, was stable over the study period for all types of cancer. Most deaths occurred within the first month of life (70.8 % of deaths). The 5-year overall survival (5-y OS) was 81.0 % (95 %CI, 79.4-82.4) with large contrasts between diagnoses. The best 5-y OS (>85 %) were observed for retinoblastomas, carcinomas, nephroblastomas, GCT, neuroblastomas, and hepatoblastomas. Conversely, the lowest 5-y OS (<65 %) were observed for acute myeloid leukemias, CNS tumors, and lymphoid leukemias. We observed no substantial change over time (80.5 % [95 %CI, 77.7-82.9] in 2000-2004 and 82.6 % [95 %CI, 80.0-84.9] in 2010-2014) for all cancers combined. The same result has been found whatever the diagnostic group.
Conclusion:
Our results contribute to better understand these tumors by quantifying their impact on the French population and assessing the burden of some devastating infant cancers.
More Related Videos
14:28Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images
Published on: July 15, 2020
10:08Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
Published on: February 24, 2021