Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions.

eLife·2026
Same author

Optimizing nanobody-based molecules targeting mesothelin: Exploring format, valency, size, and half-life for next-generation cancer theranostics.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

A Syndecan-Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies.

Journal of extracellular biology·2026
Same author

Mesothelin biology and the evolving landscape of targeted immunotherapy.

Molecular therapy. Oncology·2026
Same author

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid-β Production and Cognitive Dysfunctions in Alzheimer's Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Hour-scale single-molecule imaging reveals dynamic assembly of the Wnt co-receptors LRP6 and ROR2 into common signalosomes.

Science signaling·2026

Related Experiment Video

Updated: Dec 26, 2025

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy
08:09

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Published on: April 6, 2015

12.0K

Special Issue: Nanobody.

Patrick Chames1, Ulrich Rothbauer2,3

  • 1Aix Marseille University, CNRS, INSERM, Institute Paoli-Calmettes, CRCM, 13009 Marseille, France.

Antibodies (Basel, Switzerland)
|March 12, 2020
PubMed
Summary
This summary is machine-generated.

Camelid-derived single-domain antibody fragments are versatile binding molecules gaining attention in biotech and medicine. These heavy-chain-only antibody fragments offer unique advantages for various applications.

More Related Videos

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology
09:12

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology

Published on: May 3, 2021

2.9K
Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
11:05

Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells

Published on: February 21, 2019

9.5K

Related Experiment Videos

Last Updated: Dec 26, 2025

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy
08:09

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Published on: April 6, 2015

12.0K
Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology
09:12

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology

Published on: May 3, 2021

2.9K
Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
11:05

Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells

Published on: February 21, 2019

9.5K

Area of Science:

  • Biotechnology and Biomedical Sciences

Background:

  • Single-domain antibody fragments (SDAFs) originate from heavy-chain-only antibodies found in camelids.
  • First described in 1993, these fragments have garnered significant interest due to their unique structural and functional properties.

Discussion:

  • SDAFs exhibit remarkable stability and solubility compared to conventional antibodies.
  • Their small size allows for enhanced tissue penetration and accessibility to cryptic epitopes.

Key Insights:

  • Camelid-derived SDAFs are highly versatile binding molecules.
  • They are increasingly utilized in diverse biotechnological and medical applications.

Outlook:

  • Further research into SDAFs promises to expand their therapeutic and diagnostic potential.
  • Exploration of novel applications in drug delivery and molecular imaging is anticipated.