Related Experiment Video
Updated: Dec 26, 2025
11:23
Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
Published on: December 22, 2014
37.6K
Gut Microbial-Derived Metabolomics of Asthma
Kathleen A Lee-Sarwar1,2, Jessica Lasky-Su1, Rachel S Kelly1
1Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Metabolites
|March 12, 2020
Summary
Gut microbes produce metabolites that influence asthma development by affecting immune cell growth and bacterial load. Understanding these interactions can lead to new diagnostics and treatments for this chronic respiratory disease.
Area of Science:
- Microbiome research
- Immunology
- Metabolomics
Background:
- Asthma is a chronic respiratory disease influenced by the microbiome.
- Both gut and airway microbiomes play roles in asthma development.
- This review focuses on gut microbial metabolites and their role in immune system development.
Purpose of the Study:
- To discuss gut microbial-derived metabolites involved in asthma origins and pathophysiology.
- To explore metabolomic pathways influencing immune system ontogeny.
- To highlight the impact of microbial metabolites on asthma risk and immune function.
Main Methods:
- Literature review of studies on gut microbiome, metabolites, and asthma.
- Analysis of metabolomic pathways and their influence on immune cells.
- Examination of how microbial products affect immune function and asthma risk.
Main Results:
- Short-chain fatty acids, polyunsaturated fatty acids, and bile acids are key metabolite classes influencing asthma risk.
- Tryptophan metabolites and sphingolipids are associated with asthma, but microbiome contribution requires further research.
- Metabolites influence immune function by modulating immune cell populations and antigenic load.
Conclusions:
- Gut microbial metabolites significantly impact asthma development and immune system ontogeny.
- Further research is needed to fully elucidate the role of specific metabolites and the microbiome in asthma.
- Understanding these complex interactions can lead to targeted diagnostics and treatments for asthma.
Related Concept Videos
01:26Asthma-II: Pathophysiology and Classification
3.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K
01:20Asthma: Pathogenesis and Management
1.1K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
01:30Asthma-IV: Diagnostic and Management
3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
01:29Asthma-I: Introduction
3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
1.6K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.6K