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Updated: Dec 26, 2025
07:50
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
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[Microsatellite Instability in Gastric Cancer]
Yasuhiro Choda1, Tetsushi Kubota, Michihiro Ishida
1Dept. of Surgery, Hiroshima City Hiroshima Citizens Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 12, 2020
Summary
Microsatellite instability-high (MSI-High) gastric cancer patients showed promising response to anti-programmed death receptor-1 (PD-1) antibodies like nivolumab. This suggests PD-1 inhibitors may be effective as a secondary treatment for advanced MSI-High gastric cancer.
Area of Science:
- Oncology
- Immunotherapy
- Gastroenterology
Background:
- Pembrolizumab and nivolumab are anti-programmed death receptor-1 (PD-1) antibodies.
- Pembrolizumab is approved for unresectable or metastatic cancer with microsatellite instability-high (MSI-High) tumors.
- Limited clinical data exists on MSI in gastric cancer.
Purpose of the Study:
- To examine clinicopathological features and MSI status in patients with unresectable gastric cancer.
- To evaluate the efficacy of nivolumab in patients with unresectable gastric cancer.
- To explore the potential of anti-PD-1 antibodies in MSI-High gastric cancer.
Main Methods:
- Retrospective analysis of 37 patients with unresectable gastric cancer treated with chemotherapy since January 2019.
- Assessment of microsatellite instability (MSI) status.
- Evaluation of treatment response to nivolumab chemotherapy.
Main Results:
- MSI-High was identified in 3 patients (8.1%).
- A trend towards older age, female sex, undifferentiated type, distal lesions, and lymphatic invasion was noted in MSI-High patients, though not statistically significant.
- Four out of 11 patients (36.4%) treated with nivolumab achieved partial response (PR), and 75% of these responders were MSI-High.
Conclusions:
- Anti-PD-1 antibody therapy shows potential as a secondary treatment for unresectable or metastatic gastric cancer in MSI-High patients.
- Further research is warranted to confirm the efficacy of PD-1 inhibitors in this specific patient subgroup.
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