Related Experiment Video
Updated: Dec 26, 2025

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
Published on: June 21, 2022
Forms of prediction in the nervous system.
Christoph Teufel1, Paul C Fletcher2,3,4
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK. teufelc@cardiff.ac.uk.
Predictions shape our perception and understanding of the world. This research highlights the importance of both top-down and bottom-up predictive processing for understanding neuropsychiatric disorders.
Area of Science:
- Systems Neuroscience
- Computational Psychiatry
Background:
- The predictive processing framework is influential in systems neuroscience.
- Neuropsychiatric disorders may arise from disrupted predictive mechanisms, leading to flawed world models.
Purpose of the Study:
- To challenge the exclusive focus on top-down predictions.
- To emphasize the role of bottom-up predictive information.
- To refine the predictive processing framework for understanding neuropsychiatric disorders.
Main Methods:
- Review of existing evidence on predictive processing.
- Conceptual analysis of top-down versus bottom-up influences.
Main Results:
- Evidence supports the significance of bottom-up predictive information.
- Distinguishing between top-down and bottom-up processes is crucial.
Conclusions:
- A comprehensive predictive processing framework must integrate both top-down and bottom-up influences.
- Understanding these influences is key to explaining neuropsychiatric symptoms.
Related Concept Videos
Functions of the Nervous System
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal Communication
Synaptic Signaling
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Synaptic Signaling
Functional Divisions of the Nervous System
The sensory division transmits information from sensory receptors in the body to the CNS. It provides the CNS with knowledge about somatic senses (such as tactile, thermal, pain, and proprioceptive sensations)...

