[New approaches to embolization of aneurysms (liquid embolic agents)]

Various materials are currently available for the endovascular treatment of aneurysms. The choice of material depends on the location and configuration of the aneurysm. To ensure optimal aneurysm treatment, the filling material must incorporate the aneurysm and isolate it from the parent vessel by forming an endothelial layer and neointima proliferation along the aneurysm neck. As a result, the aneurysm can be permanently isolated from the blood flow and the weakened vessel wall can be stabilized in the long term in order to prevent subsequent rupture. Bare metal coils are currently most commonly used. In recent years, liquid embolic agents have increasingly been developed for the endovascular treatment of aneurysms. One of the reasons is that the injected fluid completely fills the aneurysm lumen, so there is no gap between the filling material and the aneurysm wall, regardless of the shape of the aneurysm. Most of the preclinical and clinical studies are available for Onyx. In particular for the treatment of mycotic aneurysms and distal aneurysms of the posterior circulation, liquid embolization with Onyx has already proven to be a possible, effective treatment method.