Related Experiment Video
Updated: Dec 26, 2025
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
16.5K
What is the future for nanocrystal-based drug-delivery systems?
Zhongjian Chen1, Wei Wu1,2, Yi Lu1,2
1Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
Therapeutic Delivery
|March 12, 2020
Summary
The future of nanocrystal drug delivery lies in cancer treatment and parenteral preparations. Advances in nanocrystal production and understanding their in vivo behavior are key to unlocking this potential.
Area of Science:
- Pharmaceutical Nanotechnology
- Drug Delivery Systems
Background:
- Nanocrystals are established drug delivery platforms for poorly water-soluble drugs, with existing commercial success in oral formulations.
- The current application of nanocrystals primarily focuses on oral drug delivery, highlighting their efficacy in this area.
Discussion:
- The study posits that the primary future applications for nanocrystal technology will be in cancer treatment and the development of parenteral (injectable) drug formulations.
- Key areas for advancement include improving techniques for producing uniform, high-quality nanocrystals and gaining a deeper understanding of their behavior within the body (in vivo fate).
Key Insights:
- The bottom-up fabrication technique offers superior control over nanocrystal particle properties.
- The hybrid nanocrystal technique presents an innovative method for investigating the in vivo fate of nanocrystals.
Outlook:
- Breakthroughs in both bottom-up and hybrid nanocrystal techniques are crucial for advancing nanocrystal development.
- Continued research in these areas will pave the way for novel cancer therapies and improved parenteral drug delivery systems.
More Related Videos
Related Concept Videos
01:16Drug Delivery: Overview
660
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
660
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.5K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.5K
01:22Drug Delivery: Miscellaneous Routes
673
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
673
01:29Drug Delivery: Parenteral Route
1.4K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
146
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
146