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Updated: Dec 26, 2025
An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
Published on: November 15, 2024
Laser Interstitial Thermal Therapy
1Albert H. Kim, MD, PhD, MSMA member since 2011, is Director, Brain Tumor Program, Associate Professor of Neurological Surgery, Genetics, Neurology, and Developmental Biology, and Bhuvic Patel, MD, Neurosurgery Resident PGY5, Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri.
Abstract:
Laser interstitial thermal therapy (LITT) is a minimally invasive and cytoreductive neurosurgical technique that has gained significant momentum in the last decade. Several technological enhancements such as MRI thermometry and improved laser probe design have enabled feasibility and improved the safety of LITT procedures. Numerous reports have been published describing the treatment of lesions ranging from tumors to epileptogenic foci, but the indications for LITT continue to evolve. We describe the general physical and biological concepts underlying LITT, clinical workflow, and established and emerging indications.
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