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Canine demodicosis: Hematological and biochemical alterations
N Y Salem1, H Abdel-Saeed1, H S Farag2
1Department of Internal Medicine and Infectious Diseases (Internal Medicine), Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Veterinary World
|March 12, 2020
Summary
Canine demodicosis disrupts oxidant-antioxidant balance, showing elevated malondialdehyde and superoxide dismutase, alongside reduced glutathione peroxidase and catalase. This parasitic skin infection also impacts acute-phase proteins like C-reactive protein.
Area of Science:
- Veterinary Dermatology
- Canine Parasitology
- Biochemistry
Background:
- Canine demodicosis is a prevalent skin disease caused by Demodex mites.
- The infection may influence the balance between oxidative stress and antioxidant defenses.
- Acute-phase proteins (APPs) like C-reactive protein (CRP) and albumin may be affected.
Purpose of the Study:
- To investigate alterations in hematological parameters.
- To assess changes in biochemical markers.
- To evaluate the oxidant-antioxidant status and APP profiles in dogs with demodicosis.
Main Methods:
- 21 dogs were studied: 7 controls and 14 with generalized demodicosis.
- Demodicosis diagnosis was confirmed via microscopy.
- Blood samples were analyzed for complete blood count (CBC), protein, liver enzymes, kidney function markers, oxidative stress markers (SOD, GPx, TAC, CAT, MDA), and CRP.
Main Results:
- Dogs with demodicosis showed decreased red blood cells and increased white blood cells.
- Elevated levels of malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were observed.
- Reduced levels of glutathione peroxidase (GPx) and catalase (CAT) were noted in affected dogs, along with increased C-reactive protein (CRP).
Conclusions:
- Canine generalized demodicosis is linked to an imbalance in oxidant-antioxidant status.
- Increased MDA and SOD, with decreased GPx and CAT, suggest reactive oxygen species (ROS) generation due to Demodex infection.
- Elevated CRP levels are indicative of inflammation associated with canine demodicosis.
