Related Experiment Video
Updated: Dec 26, 2025
13:35
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
11.5K
Relationship between Sarcopenia and Mortality in Elderly Inpatients.
Elif Bayraktar1, Pınar Tosun Tasar2, Dogan Nasır Binici1
1Department of Internal Medicine, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
The Eurasian Journal of Medicine
|March 12, 2020
Summary
Sarcopenia, the loss of muscle mass in older adults, significantly increases mortality risk in elderly hospital patients. Early identification and intervention are crucial for improving outcomes in geriatric care.
Area of Science:
- Gerontology
- Internal Medicine
- Clinical Nutrition
Background:
- Sarcopenia is a geriatric syndrome linked to adverse outcomes in elderly inpatients.
- It serves as an indicator of poor prognosis in this vulnerable population.
Purpose of the Study:
- To investigate the impact of sarcopenia on mortality rates among elderly inpatients.
- To establish the relationship between sarcopenia and clinical outcomes in a geriatric cohort.
Main Methods:
- Bioimpedance analysis was used to measure fat-free mass (FFM) in 200 geriatric inpatients.
- Fat-free mass index (FFMI) was calculated and sarcopenia was defined based on gender-specific means.
- Data were collected between Days 2 and 7 of hospitalization for mobile and immobile patients.
Main Results:
- Sarcopenia was identified in 14% of the geriatric inpatients.
- Malnourished patients had a significantly higher risk (9.046 times) of sarcopenia.
- The prevalence of sarcopenia was lower in patients with diabetes mellitus (p=0.006).
- Patients with sarcopenia experienced a higher number of deaths (p=0.012).
Conclusions:
- Sarcopenia is associated with increased mortality and longer hospital stays in geriatric inpatients.
- These findings highlight the clinical significance of sarcopenia in elderly hospital populations.
- Further research in diverse hospital settings is recommended to validate these results.
Related Concept Videos
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
193
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
193
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
142
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
142
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
150
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
150
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
145
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
145
01:15Drug Dosing: Geriatric Patients
170
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
170