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Effects of Internal Exposure to 56MnO2 Powder on Blood Parameters in Rats

Nariaki Fujimoto1, Arailym Baurzhan2, Nailya Chaizhunusova2

  • 1Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.

The Eurasian Journal of Medicine
|March 12, 2020
PubMed
Abstract

Insights

Internal manganese dioxide-56 (56MnO2) radioisotope exposure in rats caused significant biological impacts, notably altering alanine aminotransferase (ALT) levels. These findings highlight the potential health risks of radioactive manganese dioxide particle exposure.

Area of Science:

  • Radiobiology
  • Toxicology
  • Biochemistry

Background:

  • Previous studies investigated the pathological effects of internal manganese dioxide-56 (56MnO2) radioisotope particle exposure in rats.
  • This study focuses on the specific impact of 56MnO2 on blood parameters in rats.

Purpose of the Study:

  • To investigate the effects of internal exposure to manganese dioxide-56 (56MnO2) radioisotope particles on blood parameters in rats.
  • To assess changes in clinical blood parameters following exposure to varying doses of 56MnO2.

Main Methods:

  • Ten-week-old male Wistar rats were exposed to three doses of neutron-activated 56MnO2 powder, nonradioactive MnO2 powder, or external 60Co γ-rays.
  • Organ weights and clinical blood parameters were measured on days 3 and 61 postexposure.
  • Blood parameters analyzed included cell counts, electrolyte concentrations, and levels of various enzymes and metabolites.

Main Results:

  • 56MnO2 exposure resulted in accumulated doses primarily in the gastrointestinal tract, skin, and lungs, with whole-body doses ranging from 41 to 100 mGy.
  • No significant changes were observed in body weights or relative organ weights.
  • Alanine aminotransferase (ALT) levels decreased on day 3 and significantly increased on day 61 in 56MnO2-exposed groups; other blood parameters showed no exposure-related changes.

Conclusions:

  • Internal exposure to 56MnO2 powder demonstrated significant biological impacts, even at accumulated doses below 100 mGy.
  • The observed changes in ALT levels suggest a potential for delayed biological effects following 56MnO2 exposure.
  • Further research is warranted to fully elucidate the long-term toxicological profile of internal radioactive manganese dioxide exposure.
Keywords:
Blood chemistryMn-56internal radiation exposurerats

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