"Inflammaging" and bone in the OsteoLaus cohort.
Jessica Fischer1, Didier Hans2, Olivier Lamy2,3
11Faculty of Biology and Medicine, Lausanne University, Unicentre, 1015 Lausanne, Switzerland.
Immunity & Ageing : I & A
|March 12, 2020
Summary
Inflammaging, a low-grade inflammation linked to aging, does not appear to affect bone density or fracture risk in postmenopausal women. This study found no significant associations between key inflammatory markers and bone health parameters.
Area of Science:
- Gerontology
- Bone Biology
- Immunology
Background:
- Inflammaging describes the chronic, low-grade systemic inflammation associated with aging.
- While high inflammation's negative impact on bone is known, inflammaging's effects remain unclear.
Purpose of the Study:
- To investigate the association between inflammaging markers and bone health in postmenopausal women.
- To determine if low-grade inflammation impacts bone mineral density (BMD), trabecular bone score (TBS), and fracture risk.
Main Methods:
- Assessed inflammaging via cytokine levels: high-sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α).
- Measured bone parameters including prevalent and incident fractures, BMD, and TBS in 1390 postmenopausal women.
- Analyzed associations between cytokine levels and bone health indicators.
Main Results:
- No significant associations were found between IL-1β, IL-6, and TNF-α with BMD, TBS, or fractures.
- A positive association between hs-CRP and BMD/TBS was observed, but it was not significant after adjustment.
- No association was detected between hs-CRP and prevalent or incident fractures.
Conclusions:
- Low-grade cytokine levels associated with inflammaging do not appear to impact bone imaging or structure parameters.
- Bone health in postmenopausal women is not significantly affected by the typical inflammatory changes seen with aging.
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