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Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis

Mortezazadeh T^1,2, Gholibegloo E³, Riyahi Alam N¹

¹PhD, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Biomedical Physics & Engineering

|March 12, 2020

Abstract

Background:

Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.

Objective:

In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd₂O₃) coated polycyclodextrin (PCD) and modified with glucose (Gd₂O₃@PCD-Glu) for the targeting of overexpressed glucose receptors.

Material And Methods:

In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd₂O₃@PCD-Glu NPs. Furthermore, the capacity of transporting Gd₂O₃@PCD-Glu NPs to tumor cells was evaluated.

Results:

It was found that the acquired MRI T₁ signal intensity of MDA-MB-231 cells that were treated with the Gd₂O₃@PCD-Glu NPs increased significantly. Based on the results obtained, Gd₂O₃@PCD-Glu NPs can be applied in targeting Glut1-overexpressing tumor cells in vivo, as well as an MRI-targeted tumor agent to enhance tumor diagnosis.

Conclusion:

Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.

Keywords:

Contrast media Gadolinium Magnetic Resonance Imaging

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