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Serotonin and measured intelligence.

E H Cook1, B L Leventhal, D X Freedman

  • 1University of Chicago, Illinois.

Journal of Autism and Developmental Disorders
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study found no significant inverse relationship between blood serotonin and intelligence in normal adults. However, female subjects exhibited higher blood serotonin levels than males.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Elevated blood serotonin (5HT) is observed in some autistic and intellectually disabled children.
  • The relationship between blood 5HT and cognitive function in the general population is not well understood.

Purpose of the Study:

  • To investigate the correlation between whole blood serotonin levels and intelligence in normal adults.
  • To examine sex-based differences in blood serotonin levels.
  • To assess the stability of blood serotonin levels.

Main Methods:

  • Studied 98 normal adult subjects.
  • Measured whole blood serotonin (5HT) levels.
  • Assessed intelligence using Vocabulary scores.
  • Collected blood samples before and after a 450 ml volume depletion.

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Main Results:

  • A trend toward a negative correlation was observed between blood 5HT and Vocabulary scores, but it did not explain hyperserotonemia in clinical populations.
  • Female subjects had significantly higher blood 5HT levels than male subjects.
  • Blood 5HT levels remained stable before and after volume depletion.
  • No relationship was found between age and blood 5HT levels.

Conclusions:

  • Blood serotonin levels do not appear to be inversely correlated with intelligence in normal adults.
  • Sex is a significant factor influencing blood serotonin levels.
  • Blood serotonin levels demonstrate intraindividual stability.