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Updated: Dec 26, 2025

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
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Doryphagy: when selective autophagy safeguards centrosome integrity

Valentina Cianfanelli1, Francesco Cecconi1,2,3

  • 1Unit of Cell Stress and Survival, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.

Molecular & Cellular Oncology
|March 12, 2020
PubMed

Insights

A newly identified process called doryphagy selectively removes damaged Centriolar Satellites (CS). This selective autophagy maintains centrosome integrity, preventing genomic instability and inaccurate cell division common in cancer.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Centrosome abnormalities are common in cancer, but the underlying mechanisms remain unclear.
  • Understanding how centrosomes are regulated is crucial for cancer biology.

Purpose of the Study:

  • To identify novel mechanisms that maintain centrosome stability.
  • To investigate the role of autophagy in preventing centrosome-related genomic instability.

Main Methods:

  • Identification and characterization of a novel selective autophagy pathway.
  • Analysis of the role of this pathway in maintaining centrosome structure and function.
  • Investigation of the impact of this pathway on mitosis and genomic stability.

Main Results:

  • Discovery of a new selective autophagy process termed 'doryphagy'.
  • Doryphagy specifically targets Centriolar Satellites (CS) for degradation.
  • This process is essential for preserving centrosome organization and preventing inaccurate mitosis.

Conclusions:

  • Doryphagy is a critical mechanism for maintaining genomic stability by regulating centrosome integrity.
  • Targeting doryphagy could offer new therapeutic strategies for cancers with centrosome abnormalities.
Keywords:
AutophagyGABARAPGABARAPL2PCM1centriolar satellitescentrosomedoryphagymitosisselective autophagy

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