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A Population-Based Study of Device Eligibility, Use, and Reasons for Nonimplantation in Patients at Heart
Rochelle Bernier1, Jessica Ng2, Dat T Tran3
1Mazankowski Alberta Heart Institute, University of Alberta, Division of Cardiology, Edmonton, Alberta, Canada.
Insights
Only one-third of eligible patients received an implantable cardioverter defibrillator (ICD). Poor documentation for ICD nonimplantation was noted, with patient preference being a common reason.
Area of Science:
- Cardiology
- Electrophysiology
- Public Health
Background:
- Implantable cardioverter defibrillator (ICD) therapy is crucial for preventing sudden cardiac death.
- Real-world data on primary prevention ICD eligibility and utilization rates are limited.
- This study addresses the gap by examining ICD use in heart function clinic (HFC) patients.
Purpose of the Study:
- To determine the proportion of patients in heart function clinics eligible for primary prevention ICD.
- To assess the actual implantation rates among eligible patients.
- To identify reasons for nonimplantation of ICDs.
Main Methods:
- Retrospective analysis of 1239 patients from Alberta, Canada (2013-2015).
- Eligibility assessed using 2008 ACCF/AHA/HRS, 2012 ACCF/AHA/HRS Focused Update, and 2013 CCS CRT guidelines.
- Logistic regression identified predictors of nonimplantation.
Main Results:
- 45% of patients met ICD eligibility criteria; only 36% received a device.
- For 52% of nonrecipients, no reason for nonimplantation was documented.
- Patient preference (48%), older age (>75 years), and cancer history predicted nonimplantation.
Conclusions:
- A significant gap exists between ICD eligibility and implantation rates.
- Documentation of reasons for nonimplantation is inadequate.
- Patient preference and clinical factors influence ICD decisions.
Background:
Implantable cardioverter defibrillator (ICD) therapy is lifesaving; however, real-world data regarding the proportion of patients eligible for a primary prevention ICD and subsequent use remain sparse. This study evaluated rates of primary prevention ICD eligibility and use among patients in heart function clinics (HFCs) and to identify reasons for nonimplantation.
Methods:
A retrospective study was performed of patients seen at HFCs in Alberta, Canada, from 2013 to 2015. Demographics, comorbidities, clinical indications, and reasons for nonimplantation were abstracted. Eligibility was defined according to the 2008 American College of Cardiology/American Heart Association/Heart Rhythm Society ICD, 2012 American College of Cardiology/American Heart Association/Heart Rhythm Society Focused Update, and 2013 Canadian Cardiovascular Society Cardiac Resynchronization Therapy guidelines. Logistic regression was used to calculate an odds ratio (OR) and 95% confidence interval (CI) for predictors of nonimplantation.
Results:
Among 1239 patients in HFCs, the median age was 70 years (interquartile range, 59-80), 67% were male, and the median left ventricular ejection fraction was 0.40 (interquartile range, 0.28-0.53). Overall, 45% of patients (n = 553) met guideline criteria for an ICD, and of those, 36% (n = 198) received a device. Among device nonrecipients, 52% (n = 185) had no documented reason for nonimplantation. The most common reason for nonimplantation among nonrecipients was patient preference (48%). Predictors associated with nonimplantation were age more than 75 years (OR, 1.92; 95% CI, 1.31-2.82) and history of cancer (OR, 2.26; 95% CI, 1.07-4.78). At 3 years follow-up, 27% of nonrecipients were deceased.
Conclusions:
We found that one-third of patients who met guideline criteria received an ICD and that documentation for nonimplantation was poor.
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