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Author Spotlight: Studying Bacterial Growth in 3D Hydrogel Matrices

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Bacteria-laden microgels as autonomous three-dimensional environments for stem cell engineering.

K Witte¹, A Rodrigo-Navarro¹, M Salmeron-Sanchez¹

¹Center for the Cellular Microenvironment, University of Glasgow, G12 8LT, UK.

Materials Today. Bio

|March 12, 2020

Summary

This summary is machine-generated.

This study introduces a novel microfluidic system for creating 3D microgels containing stem cells and engineered bacteria. These living materials promote controlled stem cell differentiation for potential bioprinting applications.

Keywords:

Bioprinting Cell engineering Droplet-based microfluidics Engineered bacteria Living materials Stem cells

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Area of Science:

Biomaterials Engineering
Stem Cell Biology
Synthetic Biology

Background:

Stem cell differentiation is crucial for tissue regeneration.
Developing advanced biomaterials is key for controlling cellular behavior.
Engineered microorganisms offer novel therapeutic and research tools.

Purpose of the Study:

To develop a one-step microfluidic system for creating 3D alginate microgels.
To encapsulate stem cells and genetically engineered Lactococcus lactis bacteria.
To investigate the use of these living materials for controlled stem cell differentiation.

Main Methods:

Utilized a microfluidic system for high-throughput microgel formation.
Encapsulated human bone marrow-derived mesenchymal stem cells (hMSCs).
Incorporated Lactococcus lactis engineered to display fibronectin fragments and secrete bone morphogenetic protein-2 (BMP-2).

Main Results:

Achieved high monodispersity and cell viability in 3D alginate microgels.
Demonstrated that microgels promote osteogenic differentiation of hMSCs.
Developed interlinked pearl lace microgels for a tunable 3D bioprinting platform.

Conclusions:

The developed microfluidic system efficiently produces living 3D microgels.
Encapsulated engineered bacteria can direct stem cell differentiation towards osteogenesis.
This technology provides a low-cost, tunable platform for 3D bioprinting and regenerative medicine.