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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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[Specificity of estimation and prognostic value of glomerular filtration rate in older age groups with cardiovascular

N O Zakharova1, S V Bulgakova1, E V Treneva1

  • 1Samara State Medical University, 43099, Samara, Russia.

Klinicheskaia Laboratornaia Diagnostika
|March 12, 2020
PubMed

Insights

As people age, cardiovascular diseases increasingly impact health, often leading to kidney dysfunction. This study explores the combined effects of reduced kidney function and heart disease on elderly patients, highlighting the need for further research in geriatric chronic kidney disease.

Area of Science:

  • Gerontology
  • Nephrology
  • Cardiology

Background:

  • Global demographics show a rising proportion of older adults.
  • Cardiovascular diseases are a leading cause of morbidity and mortality in individuals over 60.
  • Age-related kidney changes, termed 'senile kidney,' can exacerbate cardiovascular disease complications.

Purpose of the Study:

  • To investigate the poorly understood combined impact of declining glomerular filtration rate (GFR) and cardiovascular disease on geriatric patient prognosis.
  • To underscore the clinical relevance of studying chronic kidney disease in the elderly population.

Main Methods:

  • This study focuses on the analysis of existing literature and epidemiological data.
  • It examines the relationship between age-related kidney changes, cardiovascular disease progression, and overall health outcomes in older adults.

Main Results:

  • Reduced GFR in elderly patients is often pathological, not solely age-related.
  • Cardiovascular disease significantly contributes to kidney dysfunction in older populations.
  • The interplay between declining kidney function and cardiovascular disease presents a complex challenge for geriatric health.

Conclusions:

  • Chronic kidney disease is a critical concern in geriatric patients, often linked with cardiovascular disease.
  • Further research is essential to understand and manage the combined effects of these conditions for improved patient outcomes.
  • Addressing kidney dysfunction in the context of cardiovascular health is crucial for the aging population.

Keywords:
agingchronic kidney diseasecreatininecystatin Cglomerular filtration rateurea

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