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Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

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Highly sensitive eight-channel light sensing system for biomedical applications.

Sung Bae Kim¹, Sharon Seiko Hori^2,3, Negar Sadeghipour^2,3

¹Research Institute for Environmental Management Technology, National Institute of Advanced Industrial Science and Technology (AIST), Onogawa 16-1, Tsukuba, Ibaraki, 305-8569, Japan. kimu-sb@aist.go.jp.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology

|March 12, 2020

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The Black Box I (BBI) is a new, cost-effective light sensing platform for sensitive, rapid, and portable pre-clinical imaging. It accurately measures low-level light, aiding in cancer diagnostics.

Area of Science:

Biomedical Engineering
Optical Imaging
Cancer Diagnostics

Background:

Accurate detection of low-level light is crucial for sensitive pre-clinical imaging.
Existing imaging systems can be expensive and lack portability.
Development of cost-effective, high-sensitivity instruments is needed.

Purpose of the Study:

To demonstrate the potential of the Black Box I (BBI) eight-channel light sensing platform.
To evaluate BBI's capability for rapid and sensitive measurement of low-level light.
To investigate BBI's utility in pre-clinical cancer diagnostics.

Main Methods:

Developed and characterized an eight-channel light sensing platform (BBI).
Normalized photon sensitivities using placental alkaline phosphatase (PLAP) as a reporter.

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Validated BBI performance against a reference IVIS Lumina II system and optimized photomultiplier tubes (PMT).

Main Results:

BBI showed a strong linear correlation with the IVIS Lumina II system (up to r² = 0.998 after normalization).
Successfully determined alkaline phosphatase activity in mouse plasma as a cancer biomarker.
Diagnosed cancer metastases in mice bearing triple-negative breast cancer.

Conclusions:

The Black Box I (BBI) is a promising low-cost instrument for pre-clinical diagnostic imaging.
BBI offers high sensitivity, high sample throughput, portability, and rapid on-site analysis.
This platform represents a significant addition to tools for early cancer detection and research.