A critical role for plasminogen in inflammation
Sarah K Baker1, Sidney Strickland1
1Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY.
Abstract:
Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory response in mammals. Due to these roles in inflammation, plasminogen has been implicated in the progression of a wide range of diseases with an inflammatory component. In this review, we discuss the functions of plasminogen in inflammatory regulation and how this system plays a role in the pathogenesis of diseases spanning organ systems throughout the body.
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