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3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

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Published on: May 12, 2019

Linking Structure and Function in Macroscale Brain Networks.

Laura E Suárez¹, Ross D Markello¹, Richard F Betzel²

¹McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.

Trends in Cognitive Sciences

|March 12, 2020

Summary

This summary is machine-generated.

Brain network neuroscience reveals an imperfect link between brain structure and function. Current models lack biological detail, necessitating multiscale approaches for a complete understanding.

Keywords:

connectivity connectome hierarchy network structure–function

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Area of Science:

Neuroscience
Systems Biology
Network Science

Background:

Structure-function relationships are fundamental in natural systems.
Network neuroscience highlights an imperfect link between structural and functional brain connectivity.

Purpose of the Study:

To synthesize current knowledge on brain structure-function relationships in macroscale networks.
To discuss models used to assess this relationship and identify limitations.

Main Methods:

Literature synthesis of network neuroscience research.
Analysis of existing models for brain structure-function relationships.
Discussion of future directions for multiscale modeling.

Main Results:

Current models inadequately capture the complexity of brain structure-function links.
Biological detail at molecular and cellular levels is often missing in macroscale models.

Conclusions:

Predicting brain function solely from structure is limited by current modeling approaches.
Integrating local molecular/cellular data and nuanced functional representations is key for multiscale understanding.