Related Experiment Video
Updated: Dec 26, 2025
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Propofol sedation with a target-controlled infusion pump in elderly patients undergoing ERCP
Taiji Ogawa1, Takeshi Tomoda1, Hironari Kato1
1Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Gastrointestinal Endoscopy
|March 13, 2020
Summary
Non-anesthesiologist-administered propofol (NAAP) sedation using a target-controlled infusion (TCI) system is safe for elderly patients undergoing ERCP. Elderly patients require lower propofol doses, with no increased risk of adverse events.
Area of Science:
- Gastroenterology
- Anesthesiology
- Geriatrics
Background:
- Advanced age increases risks associated with propofol sedation during endoscopic retrograde cholangiopancreatography (ERCP).
- Evaluating non-anesthesiologist-administered propofol (NAAP) sedation safety and efficacy in elderly patients is crucial.
Purpose of the Study:
- To assess the safety and efficacy of NAAP sedation with a target-controlled infusion (TCI) system in elderly patients undergoing ERCP.
- To compare propofol dosage and adverse events (AEs) across different age groups.
Main Methods:
- Retrospective analysis of 482 patients undergoing ERCP with TCI propofol sedation.
- Patients categorized into three age groups: <70 years, 70–84 years, and ≥85 years.
- Comparison of propofol dose requirements and incidence of AEs.
Main Results:
- Older age groups required significantly lower propofol doses (P < .0001).
- Incidence of hypotension (4.8%) and hypoxemia (3.3%) did not differ significantly across age groups.
- All AEs were transient, and no procedures were interrupted.
Conclusions:
- NAAP sedation with TCI is a viable option for elderly patients undergoing ERCP.
- Lower propofol dosages are effective and safe in older populations.
- This sedation method demonstrates acceptable safety profiles in the geriatric population.
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