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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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Relationship of Polymorphism of Adhesion Molecules VCAM-1 and ICAM-1 with Preeclampsia

Juanbing Wei1, Jing Lin2

  • 1Department of Obstetrics and Gynecology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China weijuanbing@163.com.

Annals of Clinical and Laboratory Science
|March 13, 2020
PubMed

Insights

Genetic variations in vascular cell adhesion molecule-1 (VCAM-1) are linked to preeclampsia (PE) risk, particularly in severe and late-onset cases. Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms showed no significant association with preeclampsia in this study.

Area of Science:

  • Genetics
  • Obstetrics
  • Immunology

Background:

  • Preeclampsia (PE) is a serious pregnancy complication.
  • Adhesion molecules like VCAM-1 and ICAM-1 play roles in vascular function and inflammation.
  • Genetic variations may influence susceptibility to PE.

Purpose of the Study:

  • To examine the association between VCAM-1 and ICAM-1 gene polymorphisms and the occurrence of preeclampsia.
  • To investigate if specific genotypes correlate with early-onset, late-onset, mild, or severe preeclampsia.

Main Methods:

  • Genotyping of VCAM-1 (rs3181092) and ICAM-1 (rs5498) polymorphisms using TaqMan assay.
  • Case-control study involving 252 PE patients and 200 healthy pregnant women.
  • Statistical analysis using SPSS 18.0.

Main Results:

  • VCAM-1 rs3181092 AA and AA+AG genotypes were significantly more prevalent in PE patients compared to controls.
  • The AA genotype of VCAM-1 was more common in late-onset and severe PE cases.
  • No significant association was found between ICAM-1 rs5498 polymorphism and preeclampsia.

Conclusions:

  • VCAM-1 rs3181092 polymorphism is associated with preeclampsia development, especially severe and late-onset forms.
  • The role of ICAM-1 rs5498 polymorphism in preeclampsia requires further research.
Abstract

Keywords:
ICAM-1VCAM-1polymorphismpreeclampsia

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