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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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M-Cdk Drives Transition Into Mitosis02:15

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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Related Experiment Video

Updated: Dec 26, 2025

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
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ctDNA Reveals Targetable Alterations

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    |March 13, 2020
    PubMed
    Summary
    This summary is machine-generated.

    In the plasmaMATCH trial, patients with advanced breast cancer received targeted therapies based on circulating tumor DNA testing. HER2 and AKT1 mutations showed promising response rates over 22% with lasting benefits.

    Area of Science:

    • Oncology
    • Genomics
    • Pharmacology

    Background:

    • Advanced breast cancer presents significant treatment challenges.

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  • Genetic alterations like ESR1, HER2, and AKT1 impact treatment efficacy.
  • Circulating tumor DNA (ctDNA) analysis offers a non-invasive method for identifying actionable mutations.