Related Experiment Video
Updated: Dec 26, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
[A case of bullous systemic lupus erythematosus with sloughing esophagitis]
Hidenori Tanaka1, Yusuke Jimbo1, Kousuke Iwane1
1Department of Gastroenterology, Sanda City Hospital.
Abstract:
A 57-year-old female presented with a chief complaint of odynophagia during medical treatment for systemic lupus erythematosus (SLE). Endoscopy revealed sloughed mucosa along the entire esophageal length, and normal mucosa was easily stripped by withdrawal of the biopsy forceps. Blistering eruptions subsequently appeared on her upper extremities, trunk, and oral cavity. Direct immunofluorescence of a skin biopsy specimen demonstrated linear deposits of IgG, IgM, and complement at the dermoepidermal junction. On the basis of these findings, a diagnosis of bullous SLE was made. This autoimmune blistering disease can occur in the course of SLE and is rarely accompanied by sloughing of the esophageal mucosa.
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