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Meningitis caused by Absidia corymbifera.

D W Mackenzie1, J F Soothill, J H Millar

  • 1Department of Microbiology, Queens University, Belfast, U.K.

The Journal of Infection
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

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A fungal infection of the brain (mucormycotic meningitis) was caused by Absidia corymbifera following a head injury. Cerebrospinal fluid showed higher antibody levels, indicating local immune response in the brain.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Mucormycosis is a rare but severe fungal infection.
  • Head trauma can create portals for opportunistic infections.

Observation:

  • A 56-year-old male patient presented with meningitis.
  • The meningitis was caused by Absidia corymbifera, a type of fungus.
  • The infection followed a penetrating head injury.

Findings:

  • Antibodies against Absidia corymbifera were detected in the patient's cerebrospinal fluid (CSF).
  • Antibody titers in the CSF were significantly higher than those in the serum.
  • This suggests local antibody production within the subarachnoid space.

Implications:

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  • The findings highlight a potential diagnostic marker for fungal meningitis.
  • Understanding local immune responses is crucial for treating CNS infections.
  • This case emphasizes the risk of fungal infections after traumatic brain injury.