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Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

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The role of cellular senescence in ageing and endocrine disease

Sundeep Khosla1,2, Joshua N Farr3,4, Tamara Tchkonia3,4

  • 1Division of Endocrinology, Mayo Clinic, Rochester, MN, USA. khosla.sundeep@mayo.edu.

Nature Reviews. Endocrinology
|March 13, 2020
PubMed

Insights

Cellular senescence, a hallmark of aging, is a promising target for treating age-related diseases. Therapies like senolytics aim to clear senescent cells, showing potential in clinical trials for endocrine and other conditions.

Area of Science:

  • Gerontology
  • Cellular Biology
  • Endocrinology

Background:

  • The global population is aging, increasing the prevalence of chronic diseases.
  • The geroscience hypothesis suggests targeting aging mechanisms can delay multiple diseases.
  • Cellular senescence is a key aging mechanism implicated in age-related diseases.

Purpose of the Study:

  • To review the mechanisms of cellular senescence.
  • To discuss therapeutic strategies targeting cellular senescence, including senolytics and SASP inhibitors.
  • To highlight the role of cellular senescence in endocrine diseases and its potential as a therapeutic target.

Main Methods:

  • Review of scientific literature on cellular senescence mechanisms.
  • Analysis of preclinical and clinical evidence for senolytic and SASP inhibitor therapies.
  • Focus on the role of cellular senescence in osteoporosis, metabolic syndrome, and type 2 diabetes mellitus.

Main Results:

  • Cellular senescence plays a causative role in multiple age-related diseases.
  • Senolytic drugs and SASP inhibitors show therapeutic potential.
  • Preclinical evidence supports senolytics for various endocrine and non-endocrine diseases.

Conclusions:

  • Cellular senescence is a critical target for combating age-related diseases.
  • Senolytics and SASP inhibitors represent promising therapeutic avenues.
  • Early clinical trials are underway, indicating significant progress in translating senolytics research into practice.

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