Related Experiment Video

Updated: Dec 26, 2025

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
08:36

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

15.4K

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Jun Yang1, Qinqing Li1

  • 1Department of Radiology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital & Cancer Center, Kunming, China.

Frontiers in Neurology
|March 13, 2020
PubMed

Insights

Manganese-enhanced MRI (MEMRI) uses Mn2+ to visualize brain structures and neural activity. This technique aids in studying central nervous system diseases, including neurodegeneration and injuries, in preclinical models.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Cellular Neuroscience

Background:

  • Manganese-enhanced MRI (MEMRI) leverages the paramagnetic properties of Mn2+.
  • Mn2+ acts as a calcium analog, entering excitable cells via voltage-gated calcium channels.
  • Fast axonal transport facilitates Mn2+ movement along neuronal axons.

Purpose of the Study:

  • To review the applications of MEMRI in studying central nervous system (CNS) diseases.
  • To highlight MEMRI's utility in preclinical models for understanding disease mechanisms.
  • To explore MEMRI's role in neuroanatomy, neural activity monitoring, and axonal transport assessment.

Main Methods:

  • Utilizing Mn2+ as a contrast agent in MRI.
  • Exploiting Mn2+ uptake through voltage-gated calcium channels.
  • Leveraging fast axonal transport for neuronal tracing.

Main Results:

  • MEMRI effectively visualizes neuroanatomical structures.
  • The technique monitors neural activity and evaluates axonal transport rates.
  • MEMRI provides valuable insights into CNS disease mechanisms in preclinical models.

Conclusions:

  • MEMRI is a versatile tool for neuroscience research.
  • Its application extends to various CNS conditions, including neurodegenerative diseases and injuries.
  • MEMRI enhances the study of disease mechanisms in preclinical settings.
Keywords:
MEMRIbrain injurycentral nervous systemmanganeseneurodegeneration

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.6K
In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

13.8K

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
8.8K
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
4.4K