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Advances in Plant-Derived Scaffold Proteins.

Congyue Annie Peng1, Lukasz Kozubowski1, William R Marcotte1

  • 1Department of Genetics and Biochemistry, Clemson University, Clemson, SC, United States.

Frontiers in Plant Science
|March 13, 2020
PubMed
Summary

Plant-derived scaffold proteins like spider silk and collagen offer sustainable solutions for regenerative medicine. Novel systems may enable cost-effective production of these vital biomaterials for drug discovery and delivery.

Keywords:
collagenelastinextracellular matrixregenerative medicinescaffoldspider silk

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Biotechnology

Background:

  • Scaffold proteins are crucial for cell adhesion and proliferation in regenerative medicine and drug screening.
  • There is a growing need for cost-effective, sustainable, hypoallergenic, and biocompatible scaffold proteins.
  • Producing large, repetitive proteins like spider silk and collagen in bacteria presents significant challenges.

Purpose of the Study:

  • To review recent advancements in plant-derived biosynthetic spider silk analogues and collagen.
  • To discuss the potential of the GAANTRY system for producing native-sized spider silk and hydroxylated collagen.
  • To explore the applications of recombinant scaffold proteins in drug delivery and discovery.

Main Methods:

  • Summarizing recent efforts in plant-based production of spider silk analogues and collagen.
  • Discussing the challenges of producing repetitive protein structures and collagen post-translational modifications in microbial hosts.
  • Proposing the GAANTRY system as a potential solution for enhanced protein production.

Main Results:

  • Plant-derived recombinant proteins offer a promising avenue for sustainable scaffold protein production.
  • Bacterial production of large, repetitive proteins and functional collagen remains challenging due to structural and modification requirements.
  • The GAANTRY system shows potential for overcoming these production hurdles.

Conclusions:

  • Recombinant scaffold proteins, particularly spider silk analogues and collagen, are vital for advancing regenerative medicine and drug screening.
  • Overcoming production challenges through innovative systems like GAANTRY is key to realizing their full potential.
  • These biomaterials hold significant promise for future applications in drug delivery and discovery.