Related Experiment Video
Updated: Dec 26, 2025
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome
Shi Tai1, Xuping Li1, Zhaowei Zhu1
1Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Insights
Hyperuricemia increases mortality risk in elderly women with acute coronary syndrome (ACS). This study found high serum uric acid levels are an independent risk factor for 1-year all-cause mortality in this vulnerable population.
Area of Science:
- Cardiology
- Geriatrics
- Metabolic Disorders
Background:
- Hyperuricemia is a known risk factor for cardiovascular diseases.
- The specific impact of hyperuricemia and sex differences on outcomes in elderly acute coronary syndrome (ACS) patients remains unclear.
Purpose of the Study:
- To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients diagnosed with ACS.
- To explore potential sex-related disparities in this association.
Main Methods:
- A retrospective cohort study involving 711 elderly ACS patients (≥75 years) hospitalized between 2013 and 2017.
- Analysis of serum uric acid (sUA) levels, in-hospital events, and 1-year mortality.
- Multivariable logistic regression was used to identify risk factors for mortality.
Main Results:
- Serum uric acid levels were significantly higher in male ACS patients compared to females.
- Elderly female ACS patients with hyperuricemia showed increased 1-year all-cause mortality.
- Hypertension prevalence was high in both sexes, with slightly higher rates in males.
Conclusions:
- Hyperuricemia is identified as an independent risk factor for 1-year all-cause mortality specifically in elderly female patients with acute coronary syndrome.
- These findings highlight the importance of considering uric acid levels in risk stratification for elderly women post-ACS.
Background:
Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS).
Objective:
To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients with ACS.
Methods:
This retrospective cohort study included 711 consecutive ACS patients aged ≥75 years, hospitalized in our center between January 2013 and December 2017. Serum uric acid (sUA), in-hospital events, and 1-year follow-up were analyzed. Multivariable logistic regression models were used to explore the risk factors for in-hospital events and 1-year all-cause mortality.
Results:
sUA levels were higher in males than in females (381.4 ± 110.1 vs. 349.3 ± 119.1 μmol/l, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%, P < 0.001). Prevalence of hypertension (80.5% vs. 72.6%.
Conclusions:
Hyperuricemia is an independent risk factor for 1-year all-cause mortality in elderly female patients with ACS.
More Related Videos
![Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F61682.jpg&w=3840&q=50)
10:02Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
Published on: October 3, 2020
07:52A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
Related Concept Videos
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:28Acute Pyelonephritis II: Diagnostic Studies and Management