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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

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The Canadian Assisted Reproductive Technologies Register (CARTR) Plus database: a validation study.

V Bacal^1,2,3, D B Fell^2,4, H Shapiro^5,6

¹Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Canada.

Human Reproduction Open

|March 13, 2020

Summary

This summary is machine-generated.

Data in the Canadian Assisted Reproductive Technologies Register (CARTR) Plus database show strong validity for most variables. Areas needing improvement include FSH levels, oocyte origin, and elective single embryo transfer documentation.

Keywords:

ART database infertility quality assurance reproductive epidemiology validation

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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

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Published on: August 25, 2019

Area of Science:

Reproductive medicine and health data management.
Assisted reproductive technologies (ART) research and data quality assessment.

Background:

Health databases are valuable research tools but require validation.
The Canadian Assisted Reproductive Technologies Register (CARTR) Plus database lacks prior validation.
Accurate documentation is crucial for research utilizing health registries.

Purpose of the Study:

To evaluate the data accuracy and completeness of the CARTR Plus database.
To assess the validity of key variables within the CARTR Plus database against patient charts.
To inform potential improvements in the CARTR Plus data entry process.

Main Methods:

Reabstracted 25 data elements from patient charts (reference standard) for 2015 IVF cycles.
Included data from six Canadian clinics using purposive and fixed random sampling.
Calculated validity measures including kappa coefficients and intraclass correlation coefficients (ICC).

Main Results:

High agreement (ICC=0.99) for patient age and nearly perfect agreement (kappa > 0.90) for cycle type and embryo transfer.
Moderate agreement for FSH levels (ICC=0.68) and oocyte origin (kappa=0.45).
Lower agreement for elective single embryo transfer (kappa=0.55).

Conclusions:

The CARTR Plus database demonstrates high data quality for most assessed variables.
Identified specific variables (FSH, oocyte origin, elective single embryo transfer) requiring improved documentation.
Further validation of additional CARTR Plus variables is recommended.