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Genetic polymorphisms and multiple myeloma risk: a meta-analysis.

Pengcheng Zhang^1,2,3, Bing Liu^4,5

¹Institute of environment and operational medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Tianjin, 300041, China. zpc546877517@163.com.

Annals of Hematology

|March 13, 2020

Summary

This meta-analysis found no significant link between common genetic variations in TNF-α, IL-6, MDR1, and MTHFR and multiple myeloma (MM) risk. Further studies on these specific polymorphisms and MM susceptibility are not recommended.

Keywords:

Interleukin-6 Methylenetetrahydrofolate reductase Multidrug resistance 1 Multiple myeloma Tumor necrosis factor-α

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Area of Science:

Genetics
Oncology
Epidemiology

Background:

Previous research on genetic polymorphisms and multiple myeloma (MM) risk has yielded conflicting findings.
Identifying genetic factors influencing MM susceptibility is crucial for understanding disease etiology.

Purpose of the Study:

To conduct a comprehensive meta-analysis assessing the association between specific genetic polymorphisms and MM risk.
To clarify the role of selected genetic variations in multiple myeloma susceptibility.

Main Methods:

Systematic literature search of PubMed and Web of Science databases (1951-August 2019).
Meta-analysis of odds ratios (OR) and 95% confidence intervals (CI) for polymorphisms in TNF-α, IL-6, MDR1, and MTHFR.
Statistical analysis to determine the overall association between genetic polymorphisms and MM risk.

Main Results:

No statistically significant association was found between multiple myeloma risk and polymorphisms in tumor necrosis factor-alpha (TNF-α) (rs1800629/rs361525/rs1799724).
Similarly, no significant associations were observed for interleukin-6 (IL-6) (rs1800795), multidrug resistance 1 (MDR1) (rs1045642), and Methylenetetrahydrofolate reductase (MTHFR) (rs1801131/rs1801133) polymorphisms with MM risk.
The meta-analysis indicates these specific genetic polymorphisms do not appear to influence susceptibility to multiple myeloma.

Conclusions:

The investigated polymorphisms in TNF-α, IL-6, MDR1, and MTHFR are unlikely to be significant risk factors for multiple myeloma.
Current evidence suggests that further research exploring the association between these specific genetic polymorphisms and MM susceptibility may not be warranted.
This meta-analysis provides clarity on the non-association of these genetic variants with MM, potentially redirecting future research efforts.