Related Experiment Video
Updated: Dec 26, 2025
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
702
Is psoriasis associated with dementia or cognitive impairment? A Critically Appraised Topic
1Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
The British Journal of Dermatology
|March 13, 2020
Summary
Psoriasis, an inflammatory condition, is linked to a higher risk of dementia and cognitive impairment. Early cognitive screening is recommended for psoriasis patients experiencing memory issues.
Area of Science:
- Neurology
- Dermatology
- Public Health
Background:
- Psoriasis is a systemic inflammatory disease with an incompletely understood link to cognitive dysfunction.
- The relationship between psoriasis and cognitive impairment or dementia requires further investigation.
Purpose of the Study:
- To synthesize evidence from observational studies on the association between psoriasis and cognitive impairment or dementia.
Main Methods:
- A systematic literature search of PubMed and Embase was performed.
- Included studies were case-control, cross-sectional, or cohort studies assessing the psoriasis-cognition link.
- Risk of bias was evaluated, and results were synthesized narratively.
Main Results:
- Eleven studies (16,574 psoriasis cases, 45,078 controls) were analyzed.
- Nine studies indicated a significant positive association between psoriasis and cognitive impairment/dementia.
- One study found a null association, and another found an inverse association.
Conclusions:
- A majority of studies suggest a positive association between psoriasis and mild cognitive impairment or dementia.
- Cognitive screening may benefit older psoriasis patients with subjective cognitive complaints.
Related Concept Videos
01:30Dementia
456
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
456
01:26Alzheimer's Disease: Overview
1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
01:22Alzheimer's Disease: Treatment
697
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
697
01:30Negative and Cognitive Symptoms of Schizophrenia
342
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
342
01:15Parkinson's Disease: Overview
1.6K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.6K
01:19Psychoneuroimmunology: Diabetes and Cancer
363
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
363