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Related Concept Videos

Fatigue01:21

Fatigue

760
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
760
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

3.8K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
3.8K

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Updated: Dec 26, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Fatigue in multiple sclerosis: Does the functional or structural damage prevail?

Massimo Bertoli1, Franca Tecchio1

  • 1LET'S - ISTC - CNR, Catholic University of the Sacred Heart, Rome, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 13, 2020
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) fatigue stems from functional brain connectivity changes, not structural damage. Treatments should target neuronal communication deficits for better outcomes.

Keywords:
EEGFatigueMRIfMRI

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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Medicine

Background:

  • Fatigue is a primary disabling symptom in multiple sclerosis (MS).
  • Current treatments for MS fatigue are largely ineffective.
  • The underlying cause of MS fatigue, whether functional or structural brain changes, remains debated.

Purpose of the Study:

  • To review and assess the prevalence of functional versus structural brain damage contributing to MS fatigue.
  • To focus on studies comparing both damage types within the same MS patients.
  • To investigate if fatigue levels correlate with clinical severity or lesion load.

Main Methods:

  • Systematic literature review of studies on MS fatigue.
  • Analysis of papers assessing functional and structural brain changes in MS patients.
  • Correlation analysis between fatigue severity, clinical scores, and neuroimaging findings.

Main Results:

  • Increased fatigue in MS is associated with altered functional connectivity at multiple neural levels.
  • No significant correlation was found between fatigue levels and lesion load or local atrophy.
  • Key alterations observed in corticomuscular coherence, interhemispheric communication, and resting-state networks (cingulate cortex, striatum, inferior parietal lobule).

Conclusions:

  • Functional neuronal network alterations, rather than structural damage, are prevalent in MS fatigue.
  • Developing treatments targeting neuronal electric communication dysfunctions is crucial for managing MS fatigue.