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Updated: Dec 26, 2025

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells
08:28

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

Published on: May 9, 2025

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Epidermal growth factor receptor (EGFR) involvement in epithelial-derived cancers and its current antibody-based

Max London1, Eugenio Gallo1

  • 1Department of Molecular Genetics, Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada.

Cell Biology International
|March 13, 2020
PubMed

Insights

Epidermal growth factor receptor (EGFR) dysregulation drives cancer. Therapeutic monoclonal antibodies targeting EGFR, like cetuximab and panitumumab, show promise in treating epithelial cancers by inhibiting tumor progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Epidermal growth factor receptor (EGFR) is a key transmembrane tyrosine kinase receptor.
  • EGFR signaling regulates critical cellular processes including proliferation, differentiation, and survival.
  • Dysregulation of EGFR is implicated in numerous human diseases, particularly epithelial-derived cancers.

Purpose of the Study:

  • To detail the role of EGFR in epithelial-derived cancers such as lung, colorectal, and squamous cell carcinomas.
  • To review the development and application of anti-EGFR anticancer agents.
  • To discuss the clinical utility of therapeutic monoclonal antibodies (mAbs) targeting EGFR.

Main Methods:

  • Review of scientific literature on EGFR function and cancer biology.
  • Analysis of the mechanisms of action for anti-EGFR therapies.
  • Discussion of clinical outcomes for EGFR-targeted treatments.

Main Results:

  • EGFR is frequently overexpressed or mutated in epithelial tumors, correlating with poor prognosis.
  • Targeted anti-EGFR therapies have shown efficacy in diminishing tumor progression and metastasis.
  • Monoclonal antibodies like cetuximab and panitumumab are effective, especially in combination with chemotherapy or radiation.

Conclusions:

  • EGFR plays a critical role in the pathogenesis of various epithelial cancers.
  • Therapeutic antibodies targeting EGFR represent a significant advancement in cancer treatment.
  • Combination therapies involving anti-EGFR mAbs offer improved outcomes for patients with EGFR-related epithelial cancers.
Keywords:
antibody therapeuticscancer therapeuticsepidermal growth factor receptoroncologyreceptor tyrosine kinase

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