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Updated: Dec 26, 2025

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
Published on: October 13, 2023
Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment
Thilanga N Pahattuge1, J Matt Jackson, Rane Digamber
1Center of BioModular Multi-Scale Systems, Department of Chemistry, University of Kansas, 1567 Irving Hill Rd., Lawrence, KS 66045, USA. ssoper@ku.edu.
Abstract:
We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400-450 nm). The PC linker allowed rapid (2 min) and efficient (>90%) release of CTCs and EVs without damaging their molecular cargo.
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