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[Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia]

    Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases
    |March 13, 2020
    PubMed

    Insights

    Chloroquine phosphate may improve treatment success and shorten hospital stays for patients with novel coronavirus pneumonia (COVID-19). This expert consensus recommends its use in mild, moderate, and severe cases lacking contraindications.

    Area of Science:

    • Virology
    • Infectious Diseases
    • Pharmacology

    Background:

    • The COVID-19 pandemic, caused by a novel coronavirus, presents a global health crisis with no specific antiviral treatments.
    • Chloroquine, an existing drug, has demonstrated broad-spectrum antiviral activity, including against coronaviruses.

    Purpose of the Study:

    • To evaluate the potential efficacy of chloroquine phosphate in treating novel coronavirus pneumonia (COVID-19).
    • To provide expert recommendations for the clinical application of chloroquine in COVID-19 patients.

    Main Methods:

    • A multicenter collaboration group developed an expert consensus based on available evidence and discussion.
    • The consensus outlines a recommended dosage and duration for chloroquine phosphate treatment.

    Main Results:

    • Preliminary findings suggest chloroquine treatment may enhance treatment success rates in COVID-19 patients.
    • Potential benefits include a shorter hospital stay and improved patient outcomes.

    Conclusions:

    • Chloroquine phosphate is recommended at a dosage of 500mg twice daily for 10 days for mild, moderate, and severe COVID-19 cases.
    • This recommendation applies to patients without contraindications to chloroquine, aiming to standardize its use in clinical practice.

    Keywords:
    ChloroquineNovel coronavirus pneumonia

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