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Updated: Dec 26, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

Ping Song1, Junqing An1, Ming-Hui Zou1

  • 1Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.

Cells
|March 14, 2020
PubMed

Insights

Senescent cells accumulate with age, causing chronic diseases. Immunotherapies that use immune cells to clear these cells show promise for treating age-related diseases and extending healthspan.

Area of Science:

  • Cellular senescence
  • Immunology
  • Gerontology

Background:

  • Senescent cells, characterized by cell cycle arrest and resistance to apoptosis, accumulate in tissues due to stressors.
  • Excessive senescent cell accumulation contributes to chronic diseases, tissue dysfunction, and organ aging.
  • Immune cells normally clear senescent cells, but impaired immune responses (immunaging) lead to persistent senescence.

Purpose of the Study:

  • To review research on senescent cells and their role in chronic diseases and aging.
  • To explore the regulation of senescence by small-molecule drugs.
  • To discuss the role of immune cells in eliminating senescent cells and the potential of senescence immunotherapies.

Main Methods:

  • Literature review of current research on cellular senescence.
  • Analysis of senolytics and senescence immunotherapies.
  • Examination of immune cell roles in senescent cell clearance.

Main Results:

  • Senescent cells drive chronic diseases and tissue aging.
  • Senolytics are emerging drugs for removing senescent cells.
  • Senescence immunotherapies utilizing immune cell-mediated clearance are promising strategies.

Conclusions:

  • Targeting senescent cells via immunotherapy can combat aging and chronic diseases.
  • Enhancing immune cell-mediated clearance of senescent cells may extend healthy lifespan.
  • Senescence immunotherapy represents a novel therapeutic avenue for age-related conditions.
Keywords:
ageingageing markerscellular senescencechronic diseasesenescence immunotherapy

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