Related Experiment Video

Updated: Dec 26, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers?

Sarah Morice1, Geoffroy Danieau1, Françoise Rédini1

  • 1INSERM, UMR1238, Bone Sarcoma and Remodeling of Calcified Tissues, Nantes University, 44035 Nantes, France.

Cancers
|March 14, 2020
PubMed

Insights

Pediatric bone sarcomas like osteosarcoma and Ewing sarcoma remain deadly, with nearly 40% of patients succumbing to the disease. Emerging research highlights the Hippo/YAP signaling pathway

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Osteosarcoma and Ewing sarcoma are the most common pediatric bone cancers.
  • Despite advances, nearly 40% of patients with these sarcomas do not survive due to metastasis or chemotherapy resistance.
  • The Hippo/YAP signaling pathway has gained attention for its role in cancer progression.

Purpose of the Study:

  • To review the current understanding of the Hippo signaling pathway's involvement in cancer.
  • To specifically examine the role of the Hippo signaling pathway in the progression of pediatric bone sarcomas.

Main Methods:

  • Literature review of studies on the Hippo signaling pathway and pediatric bone sarcomas.
  • Analysis of the pathway's functions in tumor growth, angiogenesis, epithelial to mesenchymal transition, and metastasis.

Main Results:

  • The Hippo signaling pathway influences multiple stages of tumor progression.
  • This pathway is implicated in primary tumor growth, the formation of new blood vessels (angiogenesis), and the spread of cancer cells (metastatic dissemination).

Conclusions:

  • The Hippo signaling pathway is a critical player in the progression of pediatric bone sarcomas.
  • Understanding this pathway may reveal new therapeutic targets for osteosarcoma and Ewing sarcoma.
Keywords:
Ewing sarcomaYAPhippo signaling pathwayosteosarcoma

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