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A machine learning approach on multiscale texture analysis for breast microcalcification diagnosis.

Annarita Fanizzi1, Teresa M A Basile2,3, Liliana Losurdo4

  • 1I.R.C.C.S. Istituto Tumori "Giovanni Paolo II", viale O. Flacco 65, Bari, Italy.

BMC Bioinformatics
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Summary

This study introduces an automatic model to help radiologists detect breast cancer in mammograms. The model effectively distinguishes between normal/abnormal and benign/malignant tissues, improving early cancer diagnosis.

Keywords:
Computer-aided diagnosisDigital mammogramsFeature selectionHaar wavelet transformMicrocalcificationsMinimum eigenvalue algorithmRandom forestSURF

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Oncology

Background:

  • Mammography is crucial for early breast cancer detection.
  • Radiologists face challenges in diagnosing microcalcifications.
  • An automated tool can support radiologists in mammogram interpretation.

Purpose of the Study:

  • To develop an automatic binary model for tissue discrimination in digital mammograms.
  • To compare feature selection methods for improved learning performance.
  • To enhance diagnostic support for radiologists.

Main Methods:

  • Extracted textural features using Haar wavelet decompositions.
  • Utilized Speeded Up Robust Feature (SURF) and Minimum Eigenvalue Algorithm (MinEigenAlg) for interest point detection.
  • Trained a Random Forest classifier using filter and embedded feature selection techniques.

Main Results:

  • Tested on 260 ROIs from the BCDR public database.
  • Achieved a median AUC of 98.16% for normal/abnormal classification.
  • Reached a median AUC of 92.08% for benign/malignant classification with 97.31% and 88.46% accuracy, respectively.
  • SURF and MinEigen algorithms proved informative for microcalcification characterization.

Conclusions:

  • The embedded feature selection method was more parsimonious than the filter method.
  • The developed model shows promising performance comparable to existing methods.
  • The automated system can aid radiologists in diagnosing challenging lesions like microcalcifications.