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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Periodontitis and inflammatory bowel disease: a meta-analysis.
Yang-Yang She1, Xiang-Bo Kong2,3, Ya-Ping Ge1
1Department of Stomatology, The Sixth Affiliated Hospital, Sun Yat-sen University, No.26 Yuancun Erheng Road, Tianhe District, 510655, Guangzhou, Guangdong, People's Republic of China.
BMC Oral Health
|March 14, 2020
Summary
This meta-analysis found a significant association between periodontitis and inflammatory bowel disease (IBD). Further research is needed to understand the underlying mechanisms connecting these conditions.
Area of Science:
- Gastroenterology and Periodontology
- Systemic Inflammatory Diseases
Background:
- Periodontitis, a chronic inflammatory gum disease, has been anecdotally linked to inflammatory bowel disease (IBD).
- The precise relationship between periodontitis and IBD requires further investigation to establish a definitive link.
Purpose of the Study:
- To conduct a meta-analysis to evaluate the association between periodontitis and inflammatory bowel disease (IBD).
Main Methods:
- A systematic search of electronic databases was performed for eligible studies published up to August 1, 2019.
- Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random or fixed effects models to assess the association.
Main Results:
- Six studies comprising 599 IBD patients and 448 controls were included in the meta-analysis.
- A significant pooled OR of 3.17 (95% CI: 2.09-4.8) indicated a strong association between periodontitis and IBD.
- Periodontitis was also significantly associated with Crohn's disease (OR: 3.64) and ulcerative colitis (OR: 5.37).
Conclusions:
- Periodontitis is significantly associated with an increased risk of developing inflammatory bowel disease (IBD).
- The etiological mechanisms linking periodontitis and IBD remain unclear and warrant further investigation.
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