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Meloxicam.

Nasr Y Khalil1, Khalid F Aldosari1

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|March 14, 2020
PubMed
Summary
This summary is machine-generated.

Meloxicam, a selective COX-2 inhibitor, treats inflammatory conditions like arthritis. While effective, it carries risks of gastrointestinal bleeding and ulceration, similar to other nonsteroidal anti-inflammatory drugs.

Keywords:
Analytical methodsAnti-inflammatoryMeloxicamPharmacokineticsPreparation methodThermal and spectral behavior

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Area of Science:

  • Pharmacology
  • Medicinal Chemistry

Background:

  • Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) belonging to the oxicam class.
  • It selectively inhibits cyclooxygenase-2 (COX-2).

Purpose of the Study:

  • To provide a comprehensive overview of meloxicam.
  • To detail its physical characteristics, nomenclature, preparation, analysis, pharmacokinetics, metabolism, excretion, and pharmacology.

Main Methods:

  • Review of existing literature and data on meloxicam.
  • Analysis of its chemical structure and properties.
  • Examination of its therapeutic applications and adverse effects.

Main Results:

  • Meloxicam is indicated for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and juvenile idiopathic arthritis.
  • Dosage typically starts at 7.5mg daily, with a maximum of 15mg, and is adjusted for the elderly.
  • Common side effects include abdominal pain, anemia, and edema, with a notable risk of serious gastrointestinal events.

Conclusions:

  • Meloxicam is an effective NSAID for various inflammatory conditions.
  • Physicians should be aware of its side effect profile, particularly the risk of GI complications.