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Carbetapentane citrate.

Ahmed S Abo Dena1, Alaa M Ali2, Ibrahim M El-Sherbiny2

  • 1National Organization for Drug Control and Research (NODCAR), Giza, Egypt; Nanomedicine Lab, Center for Materials Science, Zewail City of Science and Technology, 6th of October City, Giza, Egypt.

Profiles of Drug Substances, Excipients, and Related Methodology
|March 14, 2020
PubMed
Summary
This summary is machine-generated.

Carbetapentane citrate is a cough suppressant acting on peripheral nerve endings. This review compiles analytical methods for carbetapentane citrate, aiding researchers in data interpretation.

Keywords:
Analytical methodsAntitussiveCarbetapentaneCough suppressantFTIRNMRPentoxyverineThermal analysisUV spectroscopy

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Area of Science:

  • Pharmacology
  • Analytical Chemistry

Background:

  • Carbetapentane citrate is a non-opioid antitussive.
  • It is used for coughs linked to colds and respiratory infections.
  • Its mechanism resembles atropine, targeting peripheral parasympathetic nerve endings.

Purpose of the Study:

  • To provide a comprehensive analytical profile of carbetapentane citrate.
  • To consolidate existing analytical methods for carbetapentane citrate determination.
  • To facilitate easier interpretation of experimental data for researchers.

Main Methods:

  • Literature review of analytical methods for carbetapentane citrate.
  • Description and interpretation of various analytical techniques.
  • Pharmacokinetic data including Cmax and half-life.

Main Results:

  • Carbetapentane citrate achieves maximum plasma concentration (Cmax) in 2 hours.
  • The oral plasma half-life is approximately 2.3 hours.
  • Multiple analytical methods exist for its quantification.

Conclusions:

  • A consolidated analytical profile is valuable for researchers.
  • Understanding analytical methods aids in drug development and clinical use.
  • Further research may benefit from standardized analytical approaches.