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Kidney Health for Everyone Everywhere, from Prevention to Detection and Equitable Access to Care
Philip Kam-Tao Li1, Guillermo Garcia-Garcia, Siu-Fai Lui
1Department of Medicine and Therapeutics, Carol and Richard Yu PD Research Centre, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong. philipli@cuhk.edu.hk.
Insights
Chronic kidney disease (CKD) is a growing global health threat, but its progression is preventable through primary, secondary, and tertiary interventions. Increased awareness and political will are crucial for implementing effective CKD prevention strategies worldwide.
Area of Science:
- Nephrology
- Public Health
- Preventive Medicine
Background:
- Chronic kidney disease (CKD) presents a significant and escalating global health challenge, projected to become the fifth leading cause of life lost by 2040.
- CKD incurs substantial healthcare costs, with dialysis and transplantation consuming a considerable portion of national budgets in high-income nations.
- The onset and progression of CKD are largely preventable, underscoring the importance of proactive health interventions.
Discussion:
- Primary prevention involves modifying risk factors, addressing kidney abnormalities, and mitigating exposure to environmental hazards and nephrotoxins.
- Secondary prevention focuses on blood pressure and glycemic control for individuals with existing kidney disease.
- Tertiary prevention in advanced CKD patients aims to manage comorbidities like uremia and cardiovascular disease to delay or avoid renal replacement therapy.
Key Insights:
- A multi-faceted approach to CKD prevention, encompassing primary, secondary, and tertiary strategies, is essential.
- Effective CKD prevention requires targeted public health policies, professional education, and widespread public awareness campaigns.
- Political commitment is vital to integrate comprehensive CKD prevention into national health strategies.
Outlook:
- Strengthening national policies for CKD screening, management, and treatment is imperative.
- Enhancing awareness among the general population, healthcare professionals, and policymakers about preventive measures is crucial.
- A concerted global effort is needed to combat the rising burden of chronic kidney disease through robust prevention programs.
Abstract:
The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Crucially, however, the onset and progression of CKD is often preventable. In 2020, the World Kidney Day campaign highlights the importance of preventive interventions - be it primary, secondary, or tertiary. This complementing article focuses on outlining and analyzing measures that can be implemented in every country to promote and advance CKD prevention. Primary prevention of kidney disease should focus on the modification of risk factors and addressing structural abnormalities of the kidney and urinary tracts, as well as exposure to environmental risk factors and nephrotoxins. In persons with pre-existing kidney disease, secondary prevention; including blood pressure optimization and glycemic control, should be the main goal of education and clinical interventions. In patients with advanced CKD, management of co-morbidities such as uremia and cardiovascular disease is a highly recommended preventative intervention to avoid or delay dialysis or kidney transplantation. Political efforts are needed to proliferate the preventive approach. While national policies and strategies for non-communicable diseases might be present in a country, specific policies directed toward education and awareness about CKD screening, management and treatment are often lacking. Hence, there is an urgent need to increase the awareness of the importance of preventive measures throughout populations, professionals and policy makers.
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Internal Anatomy of the Kidney
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...

