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Omega-3 in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis, Effects on Inflammatory Markers and Lipid

Shadi Ziaie, Mahyar Polroudi Moghaddam, Fariba Samadian

  • 1Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. alisaffaei.ss@gmail.com.

Iranian Journal of Kidney Diseases
|March 14, 2020
PubMed

Insights

Omega-3 supplementation did not significantly alter inflammatory markers or lipid profiles in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Further large-scale trials are needed to clarify omega-3

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Chronic kidney disease (CKD) is a prevalent condition linked to high morbidity and mortality.
  • Cardiovascular disease (CVD) is a common complication in dialysis patients, necessitating preventative strategies.
  • Inflammation plays a key role in the progression of CVD in CKD patients.

Purpose of the Study:

  • To evaluate the anti-inflammatory effects of omega-3 fatty acids in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).

Main Methods:

  • Nineteen CAPD patients were enrolled and received 1g/day of omega-3 capsules for three months.
  • Inflammatory markers (ESR, CRP, HS-CRP, IL-6, MDA, homocysteine) and lipid profiles were measured.
  • Measurements were taken at three distinct phases throughout the study period.

Main Results:

  • Omega-3 supplementation did not lead to statistically significant changes in CRP, HS-CRP, homocysteine, ESR, IL-6, or lipid profiles.
  • Malondialdehyde (MDA) levels showed a significant increase (P < .05).

Conclusions:

  • This pilot study suggests omega-3 supplementation may not significantly impact most inflammatory markers or lipid profiles in CAPD patients.
  • Larger clinical trials are required to definitively ascertain the effects of omega-3 on inflammatory markers in this population.
  • Results should be interpreted with caution due to the pilot nature of the study.
Abstract

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