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Recent and current clinical trials in canine appendicular osteosarcoma
Andrew C Poon1, Arata Matsuyama1, Anthony J Mutsaers1
1Department of Biomedical Sciences (Poon, Matsuyama, Mutsaers), Department of Clinical Studies (Mutsaers), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Summary
Novel therapies are being investigated to improve outcomes for dogs with appendicular osteosarcoma (OSA). Emerging treatments in clinical trials show promise for revolutionizing care and improving survival rates for this aggressive bone cancer.
Area of Science:
- Veterinary Oncology
- Comparative Oncology
Background:
- Osteosarcoma (OSA) is an aggressive primary bone tumor in dogs, frequently affecting the appendicular skeleton.
- Current adjuvant chemotherapy offers limited survival benefits, with most dogs succumbing to metastatic disease within a year.
Purpose of the Study:
- To review emerging treatments and clinical trials for canine appendicular osteosarcoma.
- To provide a critical perspective on novel therapeutic approaches and their potential impact on survival.
Main Methods:
- Review of current scientific literature and ongoing clinical trials.
- Critical analysis of safety, efficacy, and limitations of various novel therapies.
Main Results:
- Emerging treatments include immunotherapy, virotherapy, radiotherapy, targeted therapy, and personalized medicine.
- These novel approaches mirror investigations in human oncology and represent a significant evolution in treatment strategies.
Conclusions:
- Clinical trials for canine appendicular osteosarcoma are exploring innovative therapies with the potential to revolutionize standard care.
- Successful novel treatments could significantly improve survival rates for dogs diagnosed with this challenging bone cancer.
