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Oxidative Stress in Hemodialysis Pediatric Patients

Mohamed G Shouman1, Samar Sabry2, Rasha E E Galal2

  • 1Pediatrics Department, Medical Research Division and Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt.

Open Access Macedonian Journal of Medical Sciences
|March 14, 2020
PubMed

Insights

Pediatric hemodialysis patients show increased oxidative stress, with lower levels of superoxide dismutase (SOD), arylesterase activity (ASA), and vitamin C. This oxidative stress may contribute to complications in these young patients.

Area of Science:

  • Pediatric Nephrology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Oxidative stress is implicated in hemodialysis complications like atherosclerosis, thrombosis, and inflammation.
  • Understanding oxidative stress markers is crucial for managing pediatric hemodialysis patients.

Purpose of the Study:

  • To evaluate oxidative stress in pediatric hemodialysis patients.
  • To measure oxidative stress enzymes: paraoxanase activity (PON), arylesterase activity (ASA), superoxide dismutase (SOD).
  • To assess non-enzymatic antioxidants: vitamins A, C, and E levels.

Main Methods:

  • Study included 50 pediatric hemodialysis patients and 30 healthy controls.
  • Patients' mean age was 11.4 ± 5.4 years.
  • Oxidative stress markers assessed using ELISA technique.

Main Results:

  • Hemodialysis patients had significantly lower SOD, ASA, and vitamin C levels compared to controls (p=0.004, p=0.004, p<0.001).
  • Paraoxanase activity (PON) and vitamin E levels were also evaluated.

Conclusions:

  • Oxidative stress is a common finding in pediatric hemodialysis patients.
  • Elevated oxidative stress may contribute to the complications observed in these patients.
  • Further research into antioxidant therapies is warranted.
Abstract

Keywords:
AntioxidantsArylesteraseCEHemodialysisParaoxinasePediatricSuperoxide dismutaseVitamins A

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