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High-throughput analysis of DNA repair in microplates towards identification of inhibitors

Hiroyuki Kamiya1

  • 1Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553 Japan.

Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society
|March 14, 2020
PubMed

Keywords:
Base excision repairDNA repairHigh-throughput analysis

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...